Colorectal Cancer Stem Cell Markers

The cancer stem cell concept of cancer is an emerging paradigm with accumulating supporting evidence in recent years.

Colorectal cancer stem cell markers.

Cd133 a five transmembrane glycoprotein is widely used as a marker to identify and isolate colorectal cancer stem cells. This topic remains highly controversial due to the lack of widely accepted specific molecular markers. Wnt and mammalian target of rapamycin mtor are major molecular signaling pathways associated with the development and progression of tumor as well as the maintenance and proliferation of cancer stem cells cscs in colorectal cancer crc. Colorectal cancer crc is the second most common cancer in women and the third most common in men.

1 hunan key laboratory of translational radiation oncology hunan cancer hospital and the affiliated cancer hospital of xiangya. This article reviews the current knowledge in these cancer stem cell markers and future directions of this field of research. Adenocarcinoma accounts for 90 of crc cases. Colorectal cancer stem cells cr cscs markers identification and localization of cr cscs through different markers is difficult as well as highlighting different pathways disrupted in crc.

Cancer stem cells in progression of colorectal cancer. There has been accumulating evidence in support of the cancer stem cell csc concept of cancer which proposes that cscs are central in the initiation of cancer.